GPB1
Gene Ontology Biological Process
- glucose mediated signaling pathway [IGI, IMP]
- invasive growth in response to glucose limitation [IGI, IMP]
- negative regulation of Ras protein signal transduction [IGI]
- negative regulation of phosphorylation [IGI]
- positive regulation of Ras protein signal transduction [IMP]
- protein polyubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, IMP]
- pseudohyphal growth [IGI, IMP]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GPB2
Gene Ontology Biological Process
- ascospore formation [IMP]
- glucose mediated signaling pathway [IGI, IMP]
- invasive growth in response to glucose limitation [IGI, IMP]
- negative regulation of Ras protein signal transduction [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- pseudohyphal growth [IGI, IMP]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.
G protein coupled receptors (GPCR) sense diverse ligands and signal via heterotrimeric G proteins. The Saccharomyces cerevisiae GPCR Gpr1 senses glucose and controls filamentous growth via an unusual Galpha protein, Gpa2, which lacks any known Gbetagamma subunits. Our genetic and biochemical studies identify Gpa2 interaction partners (Gpb1/2, Gpg1) and provide evidence that these proteins function as G protein subunit mimics ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: pseudohyphal growth (APO:0000029)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GPB1 GPB2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 2 | BioGRID | 3615966 | |
| GPB2 GPB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.194 | BioGRID | 354456 | |
| GPB2 GPB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.154 | BioGRID | 2076443 | |
| GPB2 GPB1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156334 |
Curated By
- BioGRID