GPB2
Gene Ontology Biological Process
- ascospore formation [IMP]
- glucose mediated signaling pathway [IGI, IMP]
- invasive growth in response to glucose limitation [IGI, IMP]
- negative regulation of Ras protein signal transduction [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- pseudohyphal growth [IGI, IMP]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GPB1
Gene Ontology Biological Process
- glucose mediated signaling pathway [IGI, IMP]
- invasive growth in response to glucose limitation [IGI, IMP]
- negative regulation of Ras protein signal transduction [IGI]
- negative regulation of phosphorylation [IGI]
- positive regulation of Ras protein signal transduction [IMP]
- protein polyubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, IMP]
- pseudohyphal growth [IGI, IMP]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth.
The yeast G(alpha) subunit Gpa2p and its coupled receptor Gpr1p function in a signaling pathway that is required for the transition to pseudohyphal and invasive growth. A two-hybrid screen using a constitutively active allele of GPA2 identified the KRH1 gene as encoding a potential binding partner of Gpa2p. Strains containing deletions of KRH1 and its homolog KRH2 were hyper-invasive and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: metabolism and growth (APO:0000094)
- phenotype: sporulation (APO:0000041)
- phenotype: temperature sensitive growth (APO:0000092)
- phenotype: invasive growth (APO:0000028)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GPB1 GPB2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 2 | BioGRID | 3615966 | |
| GPB2 GPB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.194 | BioGRID | 354456 | |
| GPB2 GPB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.154 | BioGRID | 2076443 | |
| GPB1 GPB2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156266 |
Curated By
- BioGRID