ASF1
Gene Ontology Biological Process
- DNA replication-dependent nucleosome assembly [IDA]
- DNA replication-independent nucleosome assembly [IDA]
- chromatin silencing at silent mating-type cassette [IGI]
- chromatin silencing at telomere [IGI]
- histone H2B ubiquitination [IMP]
- histone acetylation [IMP]
- histone exchange [IMP]
- nucleosome disassembly [IMP]
- positive regulation of histone acetylation [IDA, IGI, IMP, IPI]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
Gene Ontology Molecular Function
TEL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability.
Some spontaneous gross chromosomal rearrangements (GCRs) seem to result from DNA-replication errors. The chromatin-assembly factor I (CAF-I) and replication-coupling assembly factor (RCAF) complexes function in chromatin assembly during DNA replication and repair and could play a role in maintaining genome stability. Inactivation of CAF-I or RCAF increased the rate of accumulating different types of GCRs including translocations and deletion of ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mutation frequency (APO:0000198)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ASF1 TEL1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.234 | BioGRID | 218953 | |
TEL1 ASF1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.6771 | BioGRID | 324028 |
Curated By
- BioGRID