POL2
Gene Ontology Biological Process
- DNA replication proofreading [IMP]
- DNA-dependent DNA replication [IDA]
- base-excision repair [IMP]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IGI, IMP]
- error-prone translesion synthesis [IDA]
- gene conversion [IMP]
- heterochromatin organization involved in chromatin silencing [IGI, IMP]
- intra-S DNA damage checkpoint [IGI, IMP, IPI]
- leading strand elongation [IMP]
- mitotic DNA replication checkpoint [IMP]
- mitotic sister chromatid cohesion [IMP]
- nucleotide-excision repair, DNA gap filling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
POL3
Gene Ontology Biological Process
- DNA replication [IMP]
- DNA replication proofreading [IBA]
- DNA replication, removal of RNA primer [IDA]
- DNA-dependent DNA replication maintenance of fidelity [IGI]
- RNA-dependent DNA replication [IDA]
- base-excision repair, gap-filling [IBA]
- nucleotide-excision repair, DNA gap filling [IBA]
- regulation of mitotic cell cycle [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations.
BACKGROUND: DNA polymerase epsilon (Pol epsilon) is essential for S-phase replication, DNA damage repair and checkpoint control in yeast. A pol2-Y831A mutation leading to a tyrosine to alanine change in the Pol epsilon active site does not cause growth defects and confers a mutator phenotype that is normally subtle but strong in a mismatch repair-deficient strain. Here we investigate the ... [more]
Throughput
- Low Throughput
Ontology Terms
- mutation frequency (APO:0000198)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POL2 POL3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.4206 | BioGRID | 1950087 | |
| POL2 POL3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 3022295 | |
| POL2 POL3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2900697 | |
| POL3 POL2 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2452394 | |
| POL3 POL2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 463264 | |
| POL2 POL3 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158495 |
Curated By
- BioGRID