EGLN2
Gene Ontology Biological Process
- cell redox homeostasis [IDA]
- cellular response to hypoxia [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- positive regulation of protein catabolic process [IDA]
- regulation of cell growth [NAS]
- regulation of neuron apoptotic process [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [IDA]
CUL3
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.
EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (HIFα) in tumors, the functional significance and the upstream regulatory mechanisms of EglN2, especially in prostate cancer setting, remain ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID