BAIT
FGFR2
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
fibroblast growth factor receptor 2
GO Process (96)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- angiogenesis [ISS]
- axonogenesis [ISS]
- bone development [ISS]
- bone mineralization [ISS]
- bone morphogenesis [ISS]
- branch elongation involved in salivary gland morphogenesis [ISS]
- branching involved in labyrinthine layer morphogenesis [ISS]
- branching involved in prostate gland morphogenesis [ISS]
- branching involved in salivary gland morphogenesis [ISS]
- branching morphogenesis of a nerve [ISS]
- bud elongation involved in lung branching [ISS]
- cell fate commitment [ISS]
- cell-cell signaling [ISS]
- digestive tract development [ISS]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digestive tract morphogenesis [ISS]
- embryonic organ development [ISS]
- embryonic organ morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epidermis morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- epithelial cell proliferation involved in salivary gland morphogenesis [ISS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis [ISS]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [ISS]
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [ISS]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [ISS]
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [ISS]
- gland morphogenesis [ISS]
- hair follicle morphogenesis [ISS]
- in utero embryonic development [ISS]
- innate immune response [TAS]
- inner ear morphogenesis [ISS]
- insulin receptor signaling pathway [TAS]
- lacrimal gland development [ISS]
- lateral sprouting from an epithelium [ISS]
- limb bud formation [ISS]
- lung alveolus development [ISS]
- lung development [ISS]
- lung lobe morphogenesis [ISS]
- lung-associated mesenchyme development [ISS]
- mammary gland bud formation [ISS]
- membranous septum morphogenesis [ISS]
- mesenchymal cell differentiation [ISS]
- mesenchymal cell differentiation involved in lung development [ISS]
- mesenchymal cell proliferation involved in lung development [ISS]
- midbrain development [ISS]
- morphogenesis of embryonic epithelium [ISS]
- multicellular organism growth [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis [ISS]
- orbitofrontal cortex development [ISS]
- organ growth [ISS]
- organ morphogenesis [ISS]
- otic vesicle formation [ISS]
- outflow tract septum morphogenesis [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell division [ISS]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of phospholipase activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- post-embryonic development [ISS]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [ISS]
- prostate epithelial cord elongation [ISS]
- prostate gland morphogenesis [ISS]
- protein autophosphorylation [IDA]
- pyramidal neuron development [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of branching involved in prostate gland morphogenesis [ISS]
- regulation of cell fate commitment [ISS]
- regulation of fibroblast growth factor receptor signaling pathway [ISS]
- regulation of morphogenesis of a branching structure [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of osteoblast differentiation [TAS]
- regulation of osteoblast proliferation [TAS]
- regulation of smooth muscle cell differentiation [ISS]
- regulation of smoothened signaling pathway [ISS]
- reproductive structure development [ISS]
- skeletal system morphogenesis [TAS]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [ISS]
- ureteric bud development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular zone neuroblast division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FGF2
BFGF, FGF-2, FGFB, HBGF-2
fibroblast growth factor 2 (basic)
GO Process (40)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [TAS]
- branching involved in ureteric bud morphogenesis [IDA]
- cell migration involved in sprouting angiogenesis [IDA, IGI]
- chemotaxis [TAS]
- chondroblast differentiation [IDA]
- embryonic morphogenesis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- hyaluronan catabolic process [IDA]
- innate immune response [TAS]
- inositol phosphate biosynthetic process [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of wound healing [IDA]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell fate specification [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [TAS]
- release of sequestered calcium ion into cytosol [IDA]
- signal transduction [NAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.999999577 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999999577, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGFR2 FGF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9489 | BioGRID | 3549858 | |
| FGFR2 FGF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3119791 | |
| FGFR2 FGF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3300578 | |
| FGFR2 FGF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0 | BioGRID | 3511021 | |
| FGFR2 FGF2 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - | |
| FGFR2 FGF2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID