PDK4
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to fatty acid [IMP]
- cellular response to starvation [IDA]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [IMP]
- negative regulation of anoikis [IMP]
- protein phosphorylation [IDA, ISS, TAS]
- pyruvate metabolic process [TAS]
- reactive oxygen species metabolic process [IMP]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP, TAS]
- regulation of cellular ketone metabolic process [ISS]
- regulation of fatty acid biosynthetic process [IMP]
- regulation of fatty acid oxidation [ISS]
- regulation of glucose metabolic process [IMP]
- regulation of pH [ISS]
- response to starvation [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDK3
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to fatty acid [IMP]
- cellular response to glucose stimulus [ISS]
- hypoxia-inducible factor-1alpha signaling pathway [IMP]
- peptidyl-serine phosphorylation [IDA]
- peroxisome proliferator activated receptor signaling pathway [IMP]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP, TAS]
- regulation of glucose metabolic process [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.999934625 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.999934625, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDK4 PDK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 850 | BioGRID | 3484220 | |
| PDK3 PDK4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 68 | BioGRID | 3484004 | |
| PDK4 PDK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3095433 | |
| PDK4 PDK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3287967 |
Curated By
- BioGRID