PDK4
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to fatty acid [IMP]
- cellular response to starvation [IDA]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [IMP]
- negative regulation of anoikis [IMP]
- protein phosphorylation [IDA, ISS, TAS]
- pyruvate metabolic process [TAS]
- reactive oxygen species metabolic process [IMP]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP, TAS]
- regulation of cellular ketone metabolic process [ISS]
- regulation of fatty acid biosynthetic process [IMP]
- regulation of fatty acid oxidation [ISS]
- regulation of glucose metabolic process [IMP]
- regulation of pH [ISS]
- response to starvation [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDK3
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to fatty acid [IMP]
- cellular response to glucose stimulus [ISS]
- hypoxia-inducible factor-1alpha signaling pathway [IMP]
- peptidyl-serine phosphorylation [IDA]
- peroxisome proliferator activated receptor signaling pathway [IMP]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP, TAS]
- regulation of glucose metabolic process [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999999891 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999890670919, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDK4 PDK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 850 | BioGRID | 3484220 | |
| PDK3 PDK4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 68 | BioGRID | 3484004 | |
| PDK4 PDK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 2225981 | |
| PDK4 PDK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3095433 |
Curated By
- BioGRID