BAIT
TLR2
CD282, TIL4
toll-like receptor 2
GO Process (33)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- apoptotic process [TAS]
- cellular response to bacterial lipopeptide [TAS]
- cellular response to diacyl bacterial lipopeptide [IDA]
- cellular response to lipoteichoic acid [IDA]
- cellular response to triacyl bacterial lipopeptide [IDA]
- defense response to Gram-positive bacterium [IDA]
- detection of diacyl bacterial lipopeptide [IDA]
- detection of triacyl bacterial lipopeptide [IDA]
- immune response [TAS]
- innate immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [TAS]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-18 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- signal transduction [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP1M1
AP47, CLAPM2, CLTNM, MU-1A
adaptor-related protein complex 1, mu 1 subunit
GO Process (7)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.762342178 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.762342178, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID