BAIT

PTC

BcDNA:RH36596, CG2411, Conf, Dmel\CG2411, Ptc_Dm, Ptch, com4, dPtc, l(2)k02507, pat, rubr, tuf, Dmel_CG2411
patched
Drosophila melanogaster

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.

Shyamala BV, Bhat KM

The transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In vertebrates, Patched also acts as a tumor suppressor. The Patched pathway normally operates by negatively regulating Smoothened, a G-protein-coupled receptor; binding of Hedgehog ligand to Patched relieves this negative interaction and allows signaling by Smoothened. We show that Ptc regulates Drosophila head development by promoting cell ... [more]

Development Apr. 01, 2002; 129(8);1839-47 [Pubmed: 11934850]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PTC BABO
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

High-BioGRID
443945

Curated By