PTC
Gene Ontology Biological Process
- Bolwig's organ morphogenesis [IMP]
- anterior/posterior lineage restriction, imaginal disc [TAS]
- anterior/posterior pattern specification [NAS]
- axon guidance [IMP]
- blastoderm segmentation [NAS]
- dephosphorylation [TAS]
- determination of genital disc primordium [IMP]
- embryonic pattern specification [TAS]
- eye-antennal disc morphogenesis [IMP]
- germ-line stem cell division [TAS]
- gonad development [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- lipid homeostasis [IMP]
- negative regulation of smoothened signaling pathway [IGI, TAS]
- oogenesis [IMP]
- ovarian follicle cell development [TAS]
- peripheral nervous system development [TAS]
- proteolysis [TAS]
- regulation of apoptotic process [IGI]
- regulation of epithelial cell migration, open tracheal system [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of protein import into nucleus [IMP]
- smoothened signaling pathway [IGI, IMP, NAS, TAS]
- somatic stem cell division [TAS]
- wing disc anterior/posterior pattern formation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BABO
Gene Ontology Biological Process
- activin receptor signaling pathway [IDA]
- axon guidance [IMP]
- dendrite morphogenesis [NAS]
- determination of adult lifespan [IMP]
- eye-antennal disc morphogenesis [IGI]
- imaginal disc-derived wing morphogenesis [IMP]
- mushroom body development [IMP]
- negative regulation of autophagy [IMP]
- neuroblast proliferation [IMP]
- neuron development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- protein phosphorylation [ISS, NAS]
- regulation of mitotic cell cycle [IMP]
- response to UV [IDA]
- signal transduction [ISS]
- transforming growth factor beta receptor signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.
The transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In vertebrates, Patched also acts as a tumor suppressor. The Patched pathway normally operates by negatively regulating Smoothened, a G-protein-coupled receptor; binding of Hedgehog ligand to Patched relieves this negative interaction and allows signaling by Smoothened. We show that Ptc regulates Drosophila head development by promoting cell ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTC BABO | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 443945 |