PTC
Gene Ontology Biological Process
- Bolwig's organ morphogenesis [IMP]
- anterior/posterior lineage restriction, imaginal disc [TAS]
- anterior/posterior pattern specification [NAS]
- axon guidance [IMP]
- blastoderm segmentation [NAS]
- dephosphorylation [TAS]
- determination of genital disc primordium [IMP]
- embryonic pattern specification [TAS]
- eye-antennal disc morphogenesis [IMP]
- germ-line stem cell division [TAS]
- gonad development [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- lipid homeostasis [IMP]
- negative regulation of smoothened signaling pathway [IGI, TAS]
- oogenesis [IMP]
- ovarian follicle cell development [TAS]
- peripheral nervous system development [TAS]
- proteolysis [TAS]
- regulation of apoptotic process [IGI]
- regulation of epithelial cell migration, open tracheal system [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of protein import into nucleus [IMP]
- smoothened signaling pathway [IGI, IMP, NAS, TAS]
- somatic stem cell division [TAS]
- wing disc anterior/posterior pattern formation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BABO
Gene Ontology Biological Process
- activin receptor signaling pathway [IDA]
- axon guidance [IMP]
- dendrite morphogenesis [NAS]
- determination of adult lifespan [IMP]
- eye-antennal disc morphogenesis [IGI]
- imaginal disc-derived wing morphogenesis [IMP]
- mushroom body development [IMP]
- negative regulation of autophagy [IMP]
- neuroblast proliferation [IMP]
- neuron development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- protein phosphorylation [ISS, NAS]
- regulation of mitotic cell cycle [IMP]
- response to UV [IDA]
- signal transduction [ISS]
- transforming growth factor beta receptor signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction mapping: a Drosophila case study.
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries. More than 2300 protein-protein interactions (PPI) were identified, of ... [more]
Throughput
- High Throughput
Additional Notes
- Predicted Biological Score:D
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTC BABO | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - |
Curated By
- BioGRID