FAF
Gene Ontology Biological Process
- cellularization [IMP]
- compound eye development [IMP]
- defense response to Gram-negative bacterium [IMP]
- dorsal/ventral axis specification [IGI, IMP]
- embryo development [IMP]
- endocytosis [NAS]
- germ cell migration [TAS]
- mystery cell differentiation [IMP, TAS]
- negative regulation of innate immune response [IMP]
- negative regulation of proteolysis [NAS]
- nuclear migration [IMP]
- protein deubiquitination [IDA, IMP, NAS, TAS]
- ubiquitin-dependent protein catabolic process [IGI]
Gene Ontology Molecular Function
LQF
Gene Ontology Biological Process
- autophagy [IDA]
- endocytosis [IMP, NAS, TAS]
- negative regulation of cardioblast cell fate specification [IMP]
- neurotransmitter secretion [NAS]
- positive regulation of Notch signaling pathway [IMP]
- regulation of Notch signaling pathway [IMP]
- storage protein import into fat body [IDA]
- synaptic vesicle endocytosis [NAS]
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Mutagenesis screens for interacting genes reveal three roles for fat facets during Drosophila eye development.
The Drosophila fat facets gene encodes a deubiquitinating enzyme that regulates a cell communication pathway essential early during eye development to inhibit the determination of excess photoreceptors. Ubiquitin is a small polypeptide that tags proteins for degradation by a multisubunit proteolytic complex called the proteasome. The FAT FACETS protein is thought to be required to remove ubiquitin from a particular ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LQF FAF | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FAF LQF | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| FAF LQF | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - |