FAF
Gene Ontology Biological Process
- cellularization [IMP]
- compound eye development [IMP]
- defense response to Gram-negative bacterium [IMP]
- dorsal/ventral axis specification [IGI, IMP]
- embryo development [IMP]
- endocytosis [NAS]
- germ cell migration [TAS]
- mystery cell differentiation [IMP, TAS]
- negative regulation of innate immune response [IMP]
- negative regulation of proteolysis [NAS]
- nuclear migration [IMP]
- protein deubiquitination [IDA, IMP, NAS, TAS]
- ubiquitin-dependent protein catabolic process [IGI]
Gene Ontology Molecular Function
LQF
Gene Ontology Biological Process
- autophagy [IDA]
- endocytosis [IMP, NAS, TAS]
- negative regulation of cardioblast cell fate specification [IMP]
- neurotransmitter secretion [NAS]
- positive regulation of Notch signaling pathway [IMP]
- regulation of Notch signaling pathway [IMP]
- storage protein import into fat body [IDA]
- synaptic vesicle endocytosis [NAS]
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis.
Fat facets is a deubiquitinating enzyme required in a cell communication pathway that limits to eight the number of photoreceptor cells in each facet of the Drososphila compound eye. Genetic data support a model whereby Faf removes ubiquitin, a polypeptide tag for protein degradation, from a specific ubiquitinated protein thus preventing its degradation. Here, mutations in the liquid facets gene ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
LQF FAF | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
FAF LQF | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
FAF LQF | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - |