SXL
Gene Ontology Biological Process
- alternative mRNA splicing, via spliceosome [TAS]
- dosage compensation [NAS, TAS]
- female germ-line sex determination [TAS]
- female sex determination [NAS]
- female somatic sex determination [TAS]
- germ cell development [TAS]
- imaginal disc growth [IMP]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of mRNA splicing, via spliceosome [TAS]
- negative regulation of translation [IDA, IMP, NAS, TAS]
- oocyte differentiation [IDA]
- oogenesis [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- regulation of mRNA splicing, via spliceosome [NAS, TAS]
- sex determination [NAS, TAS]
- sex determination, primary response to X:A ratio [NAS, TAS]
- sex differentiation [NAS, TAS]
- smoothened signaling pathway [IDA]
- somatic sex determination [NAS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRA
Gene Ontology Biological Process
- RNA splicing [TAS]
- female sex determination [IMP]
- female sex differentiation [IDA]
- female somatic sex determination [TAS]
- mRNA splicing, via spliceosome [IDA, NAS, TAS]
- male courtship behavior, veined wing generated song production [IMP]
- negative regulation of translation [NAS]
- sex determination [TAS]
- sex determination, primary response to X:A ratio [NAS]
- sex differentiation [TAS]
- somatic sex determination [NAS]
- spliceosomal complex assembly [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila.
Alternative splicing controls the expression of many genes, including the Drosophila sex determination gene Sex-lethal (Sxl). Sxl expression is controlled via a negative regulatory mechanism where inclusion of the translation-terminating male exon is blocked in females. Previous studies have shown that the mechanism leading to exon skipping is autoregulatory and requires the SXL protein to antagonize exon inclusion by interacting ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SXL TRA | Affinity Capture-RNA Affinity Capture-RNA An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis. | Low | - | FlyBase | - | |
| SXL TRA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| SXL TRA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| SXL TRA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| SXL TRA | Protein-RNA Protein-RNA An interaction is detected between and protein and an RNA in vitro. | Low | - | FlyBase | - |