SXL
Gene Ontology Biological Process
- alternative mRNA splicing, via spliceosome [TAS]
- dosage compensation [NAS, TAS]
- female germ-line sex determination [TAS]
- female sex determination [NAS]
- female somatic sex determination [TAS]
- germ cell development [TAS]
- imaginal disc growth [IMP]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of mRNA splicing, via spliceosome [TAS]
- negative regulation of translation [IDA, IMP, NAS, TAS]
- oocyte differentiation [IDA]
- oogenesis [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- regulation of mRNA splicing, via spliceosome [NAS, TAS]
- sex determination [NAS, TAS]
- sex determination, primary response to X:A ratio [NAS, TAS]
- sex differentiation [NAS, TAS]
- smoothened signaling pathway [IDA]
- somatic sex determination [NAS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRA
Gene Ontology Biological Process
- RNA splicing [TAS]
- female sex determination [IMP]
- female sex differentiation [IDA]
- female somatic sex determination [TAS]
- mRNA splicing, via spliceosome [IDA, NAS, TAS]
- male courtship behavior, veined wing generated song production [IMP]
- negative regulation of translation [NAS]
- sex determination [TAS]
- sex determination, primary response to X:A ratio [NAS]
- sex differentiation [TAS]
- somatic sex determination [NAS]
- spliceosomal complex assembly [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.
Somatic sexual differentiation in Drosophila melanogaster involves a cascade of regulated splicing events and provides an attractive model system for the analysis of alternative splicing mechanisms. The protein Sex-lethal (Sxl) activates a female-specific 3' splice site in the first intron of transformer (tra) pre-mRNA while repressing an alternative non-sex-specific site. We have developed an in vitro system that recapitulates this ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SXL TRA | Affinity Capture-RNA Affinity Capture-RNA An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis. | Low | - | FlyBase | - | |
| SXL TRA | Affinity Capture-RNA Affinity Capture-RNA An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis. | Low | - | FlyBase | - | |
| SXL TRA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| SXL TRA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| SXL TRA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - |