EMC
Gene Ontology Biological Process
- R3/R4 cell differentiation [IMP]
- R7 cell differentiation [IMP]
- R8 cell fate commitment [NAS]
- brain morphogenesis [IMP]
- cell proliferation [IGI, IMP]
- chaeta morphogenesis [TAS]
- chorion-containing eggshell pattern formation [IMP]
- compound eye cone cell differentiation [IMP]
- dorsal appendage formation [IMP]
- dorsal closure [IMP]
- head involution [IMP]
- imaginal disc-derived wing morphogenesis [IGI, IMP]
- imaginal disc-derived wing vein morphogenesis [IGI, IMP]
- inter-male aggressive behavior [IMP]
- lateral inhibition [IMP]
- locomotion involved in locomotory behavior [IMP]
- midgut development [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- peripheral nervous system development [IMP]
- photoreceptor cell fate commitment [IMP]
- progression of morphogenetic furrow involved in compound eye morphogenesis [IMP]
- sex determination [IGI]
- sex determination, primary response to X:A ratio [TAS]
- spermatid development [IMP]
- startle response [IMP]
Gene Ontology Molecular Function
DA
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.
During development, the rate of cell proliferation must be constantly monitored so that an individual tissue achieves its correct size. Mutations in genes that normally promote tissue growth often result in undersized, disorganized and non-functional organs. However, mutations in genes that encode growth inhibitors can trigger the onset of tumorigenesis and cancer. The developing eye of the fruit fly, Drosophila ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EMC DA | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | FlyBase | - | |
| EMC DA | PCA PCA A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay. | Low | - | BioGRID | 2773605 | |
| EMC DA | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | FlyBase | - | |
| EMC DA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | FlyBase | - | |
| EMC DA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | FlyBase | - | |
| EMC DA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |