BAIT
DLD
DLDD, DLDH, E3, GCSL, LAD, PHE3, tcag7.39
dihydrolipoamide dehydrogenase
GO Process (8)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
- branched-chain amino acid catabolic process [TAS]
- cellular metabolic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- lysine catabolic process [TAS]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [TAS]
- small molecule metabolic process [TAS]
- tricarboxylic acid cycle [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
MIF
GIF, GLIF, MMIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
GO Process (21)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- carboxylic acid metabolic process [IDA]
- cell proliferation [IDA]
- cell surface receptor signaling pathway [IDA]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell aging [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive chemotaxis [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein kinase A signaling [IDA]
- prostaglandin biosynthetic process [IDA]
- protein homotrimerization [IPI]
- regulation of macrophage activation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Mitochondrial protein (MP) dysfunction has been linked to neurodegenerative disorders (NDs); however, the discovery of the molecular mechanisms underlying NDs has been impeded by the limited characterization of interactions governing MP function. Here, using mass spectrometry (MS)-based analysis of 210 affinity-purified mitochondrial (mt) fractions isolated from 27 epitope-tagged human ND-linked MPs in HEK293 cells, we report a high-confidence MP network ... [more]
Cell Syst Nov. 07, 2017; (); [Pubmed: 29128334]
Quantitative Score
- 0.00086307 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- HEK293 cell line (Antibody; IP/MS)
- HEK293 cell line (FLAG TAGGED; AP/MS)
- Normalized Spectral Abundance Factor (NSAF) scores were associated with each mitochondrial protein (MP) interaction. High confidence MP interactions were filtered at a confidence threshold of 90%.
Curated By
- BioGRID