A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast Csk1 is a CAK-activating kinase (CAKAK).

Hermand D, Pihlak A, Westerling T, Damagnez V, Vandenhaute J, Cottarel G, Maekelae TP

Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several ... [more]

EMBO J. Dec. 15, 1998; 17(24);7230-8 [Pubmed: 9857180]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CSK1 MCS6	Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.	Hermand D (1998)	Low	-	BioGRID	250547
CSK1 MCS6	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Lee KM (1999)	Low	-	BioGRID	247376
CSK1 MCS6	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Saiz JE (2002)	Low	-	BioGRID	246714
CSK1 MCS6	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Hermand D (1998)	Low	-	BioGRID	246333
CSK1 MCS6	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Hermand D (2001)	Low	-	BioGRID	246335
MCS6 CSK1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Hermand D (2001)	Low	-	BioGRID	246336

Curated By

BioGRID

Interaction Summary

MCS6

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II carboxy-terminal domain kinase activity [IDA]cyclin-dependent protein kinase activating kinase activity [IDA, IGI]

Gene Ontology Cellular Component

CSK1

Gene Ontology Biological Process

Gene Ontology Molecular Function

cyclin-dependent protein kinase activating kinase activity [IGI]cyclin-dependent protein serine/threonine kinase regulator activity [IMP]protein kinase activator activity [IDA]protein kinase activity [IDA]protein serine/threonine kinase activity [IDA]