PDS5
Gene Ontology Biological Process
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation [IMP]
- cellular protein localization [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome passenger complex localization to kinetochore [IMP]
- mitotic sister chromatid cohesion [IGI]
- mitotic sister chromatid segregation [IMP]
- protein localization to chromosome, centromeric region [IMP]
- protein localization to kinetochore [IMP]
- regulation of histone H3-T3 phosphorylation [IDA]
- regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MIS4
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular response to nitrogen starvation [IMP]
- cohesin localization to chromatin [IMP]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle organization [IMP]
- negative regulation of G0 to G1 transition [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast Pds5 is required for accurate chromosome segregation and for survival after DNA damage or metaphase arrest.
Sister chromatid cohesion, which is established during the S phase of the eukaryotic cell cycle and persists until the onset of anaphase, is essential for the maintenance of genomic integrity. Cohesion requires the multi-protein complex cohesin, as well as a number of accessory proteins including Pds5/BIMD/Spo76. In the budding yeast Saccharomyces cerevisiae Pds5 is an essential protein that localises to ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MIS4 PDS5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 735429 | |
| MIS4 PDS5 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 449973 |
Curated By
- BioGRID