BAIT

CRB2

rhp9, SPBC342.05
DNA repair protein Rad9 homolog, Rhp9
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

POL1

polA, swi7, SPAC3H5.06c
DNA polymerase alpha catalytic subunit
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.

Grenon M, Tillit J, Piard K, Baldacci G, Francesconi S

We have isolated a mutant in fission yeast, in which mitosis is uncoupled from completion of DNA replication when DNA synthesis is impaired by a thermosensitive mutation in the gene encoding the catalytic subunit of DNA polymerase delta. By functional complementation, we cloned the wild-type gene and identified it as the recently cloned checkpoint gene crb2+/rhp9+. This gene has been ... [more]

Mol. Gen. Genet. Jan. 01, 1999; 260(6);522-34 [Pubmed: 9928931]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: mitotic cell cycle (APO:0000072)
  • phenotype: inviable (APO:0000112)

Additional Notes

  • double mutants show mitotic catastrophe

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CRB2 POL1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
247057
POL1 CRB2
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
798430
POL1 CRB2
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
795461

Curated By

  • BioGRID