PARK2
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
HIF1A
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- axon transport of mitochondrion [IMP]
- cellular response to hypoxia [IDA, IEP, TAS]
- cellular response to interleukin-1 [IEP]
- collagen metabolic process [ISS]
- connective tissue replacement involved in inflammatory response wound healing [ISS]
- elastin metabolic process [ISS]
- epithelial to mesenchymal transition [ISS]
- mRNA transcription from RNA polymerase II promoter [IC]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- oxygen homeostasis [IDA]
- positive regulation of angiogenesis [IC]
- positive regulation of chemokine production [TAS]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of epithelial cell migration [ISS]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [TAS]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, IMP]
- regulation of gene expression [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- regulation of transcription, DNA-templated [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IDA, IMP]
- signal transduction [IMP]
- vascular endothelial growth factor production [IDA]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- enzyme binding [IPI]
- histone acetyltransferase binding [IPI]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI, TAS]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1α (HIF-1α). Parkin interacts with HIF-1α and promotes HIF-1α degradation through ubiquitination, which in turn inhibits metastasis of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARK2 HIF1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| PARK2 HIF1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HIF1A PARK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HIF1A PARK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PARK2 HIF1A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2470655 | |
| PARK2 HIF1A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| HIF1A PARK2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID