CIG2
Gene Ontology Biological Process
- negative regulation of conjugation with cellular fusion [IMP]
- negative regulation of induction of conjugation with cellular fusion [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IGI, IMP]
- positive regulation of protein serine/threonine kinase activity [IDA]
- signal transduction involved in G1 cell size control checkpoint [IGI]
- traversing start control point of mitotic cell cycle [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RUM1
Gene Ontology Biological Process
- G1 cell size control checkpoint [IDA]
- cellular response to nitrogen starvation [IMP]
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- mitotic cell cycle arrest in response to pheromone [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- negative regulation of mitotic DNA replication initiation [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- regulation of mitotic DNA replication initiation [IGI]
- signal transduction [TAS]
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.
Eukaryotic cells coordinate cell size with cell division by regulating the length of the G1 and G2 phases of the cell cycle. In fission yeast, the length of the G1 phase depends on a precise balance between levels of positive (cig1, cig2, puc1, and cdc13 cyclins) and negative (rum1 and ste9-APC) regulators of cdc2. Early in G1, cyclin proteolysis and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression (APO:0000253)
Additional Notes
- The cell cycle defect seen in CIG1/CIG2/PUC1 triple mutants can be rescued by deletion of RUM1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CIG2 RUM1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| RUM1 CIG2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CIG2 RUM1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 737428 | |
| CIG2 RUM1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 247387 | |
| CIG2 RUM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247140 |
Curated By
- BioGRID