CIG2
Gene Ontology Biological Process
- negative regulation of conjugation with cellular fusion [IMP]
- negative regulation of induction of conjugation with cellular fusion [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IGI, IMP]
- positive regulation of protein serine/threonine kinase activity [IDA]
- signal transduction involved in G1 cell size control checkpoint [IGI]
- traversing start control point of mitotic cell cycle [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RUM1
Gene Ontology Biological Process
- G1 cell size control checkpoint [IDA]
- cellular response to nitrogen starvation [IMP]
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- mitotic cell cycle arrest in response to pheromone [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- negative regulation of mitotic DNA replication initiation [IMP]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- regulation of mitotic DNA replication initiation [IGI]
- signal transduction [TAS]
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.
The fission yeast Schizosaccharomyces pombe can be induced to perform multiple rounds of DNA replication without intervening mitoses by manipulating the activity of the cyclin-dependent kinase p34(cdc2). We have examined the role in this abnormal rereplication of a large panel of genes known to be involved in normal S phase. The genes analyzed can be grouped into four classes: (1) ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell cycle progression (APO:0000253)
- phenotype: cell shape (APO:0000051)
- phenotype: cell cycle progression (APO:0000253)
- phenotype: cell shape (APO:0000051)
Additional Notes
- genetic complex
- overexpression of rum1 in a cig1/cig2 double mutant causes cell cycle arrest
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CIG2 RUM1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| RUM1 CIG2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CIG2 RUM1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 737428 | |
| CIG2 RUM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247140 | |
| CIG2 RUM1 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 247084 |
Curated By
- BioGRID