A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.

Kinoshita N, Ohkura H, Yanagida M

The activities of type 1 protein phosphatase (PP1) and 2A (PP2A) have distinct, essential roles in cell cycle control. Two previously identified PP1 genes (dis2+ and sds21+) and two PP2A genes (ppa1+ and ppa2+), highly homologous to mammalian PP2A, have been isolated from fission yeast. Only double gene disruption of both PP2A genes results in lethality, as is the case ... [more]

Cell Oct. 19, 1990; 63(2);405-15 [Pubmed: 2170029]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
DIS2 SDS21	Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.	Alvarez-Tabares I (2007)	Low	-	BioGRID	-
DIS2 SDS21	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Ohkura H (1989)	Low	-	BioGRID	300800

Curated By

BioGRID

Interaction Summary

DIS2

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphoprotein phosphatase activity [IDA]protein serine/threonine phosphatase activity [IDA]

Gene Ontology Cellular Component

SDS21