LRRK1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCL21
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- T cell costimulation [ISS]
- activation of Rho GTPase activity [IDA]
- cell chemotaxis [IDA]
- cell maturation [ISS]
- cell-cell signaling [TAS]
- dendritic cell chemotaxis [IDA]
- dendritic cell dendrite assembly [ISS]
- establishment of T cell polarity [IDA]
- immunological synapse formation [ISS]
- inflammatory response [NAS]
- mesangial cell-matrix adhesion [IDA]
- negative regulation of dendritic cell dendrite assembly [ISS]
- negative regulation of leukocyte apoptotic process [IDA]
- negative regulation of leukocyte tethering or rolling [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell motility [IDA]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of filopodium assembly [IDA]
- positive regulation of glycoprotein biosynthetic process [ISS]
- positive regulation of myeloid dendritic cell chemotaxis [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of pseudopodium assembly [IDA]
- positive regulation of receptor-mediated endocytosis [ISS]
- release of sequestered calcium ion into cytosol [IDA]
- response to prostaglandin E [IDA]
- ruffle organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.
Signal transduction cascades governed by kinases and GTPases are a critical component of the command and control of cellular processes, with the precise outcome partly determined by direct protein-protein interactions (PPIs). Here, we use the human ROCO proteins as a model for investigating PPI signaling events-taking advantage of the unique dual kinase/GTPase activities and scaffolding properties of these multidomain proteins. ... [more]
Throughput
- High Throughput
Additional Notes
- Significant hits in the protein microarray had a Z-score threshold of Z > 3.
Curated By
- BioGRID