DRD3
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- acid secretion [ISS]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- arachidonic acid secretion [IDA]
- behavioral response to cocaine [IEP, ISS]
- cellular calcium ion homeostasis [IDA]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- learning [NAS]
- learning or memory [NAS]
- locomotory behavior [ISS]
- musculoskeletal movement, spinal reflex action [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- positive regulation of cytokinesis [IMP]
- positive regulation of dopamine receptor signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- prepulse inhibition [IMP]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine secretion [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to cocaine [IEP]
- response to drug [ISS]
- response to ethanol [ISS]
- response to histamine [IDA]
- response to morphine [ISS]
- social behavior [NAS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DRD1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IDA]
- activation of adenylate cyclase activity [IDA]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- cellular response to catecholamine stimulus [IDA]
- cerebral cortex GABAergic interneuron migration [ISS]
- dopamine metabolic process [IC]
- mating behavior [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IDA, IGI]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of potassium ion transport [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- prepulse inhibition [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to drug [ISS]
- synapse assembly [ISS]
- transmission of nerve impulse [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization.
Colocalization of dopamine D1 (D1R) and D3 receptors (D3R) in specific neuronal populations suggests that their functional cross-talk might involve direct interactions. Here we report that the D1R coimmunoprecipitates with the D3R from striatal protein preparations, suggesting that they are clustered together in this region. Using bioluminescence resonance energy transfer (BRET(2)), we further suggest the existence of a physical interaction ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DRD1 DRD3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DRD1 DRD3 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | 2632315 |
Curated By
- BioGRID