DYRK1A
Gene Ontology Biological Process
- circadian rhythm [ISS]
- mitotic cell cycle [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- nervous system development [TAS]
- peptidyl-threonine phosphorylation [ISS]
- peptidyl-tyrosine phosphorylation [IDA, ISS]
- positive regulation of protein deacetylation [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TSC2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cell cycle arrest [TAS]
- endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- negative regulation of TOR signaling [IBA]
- negative regulation of Wnt signaling pathway [IBA]
- negative regulation of cell proliferation [ISS]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISS]
- negative regulation of protein kinase B signaling [IBA, ISS]
- negative regulation of protein kinase activity [ISS]
- neural tube closure [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [ISS]
- positive regulation of Ras GTPase activity [IBA]
- protein import into nucleus [ISS]
- protein kinase B signaling [ISS]
- protein localization [ISS]
- regulation of cell cycle [IBA]
- regulation of endocytosis [ISS]
- regulation of insulin receptor signaling pathway [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.
The chromosome 21 encoded protein kinase DYRK1A is essential for normal human development. Mutations in DYRK1A underlie a spectrum of human developmental disorders, and increased dosage in trisomy 21 is implicated in Down syndrome related pathologies. DYRK1A regulates a diverse array of cellular processes through physical interactions with substrates and binding partners in various subcellular compartments. Despite recent large-scale protein-protein ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DYRK1A TSC2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2633291 | |
| DYRK1A TSC2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3775538 |
Curated By
- BioGRID