BAIT
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FKBP1A
FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE, RP11-314N13.2
FK506 binding protein 1A, 12kDa
GO Process (26)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- SMAD protein complex assembly [IDA]
- T cell activation [NAS]
- amyloid fibril formation [IDA]
- calcium ion transmembrane transport [NAS]
- chaperone-mediated protein folding [IBA]
- extracellular fibril organization [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [NAS]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of activin receptor signaling pathway [IDA]
- regulation of amyloid precursor protein catabolic process [IGI]
- regulation of immune response [IMP]
- regulation of protein localization [IGI]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, ISS]
- transforming growth factor beta receptor signaling pathway [TAS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
- FK506 binding [IDA, NAS]
- SMAD binding [IPI]
- activin binding [IPI]
- calcium channel inhibitor activity [IDA]
- ion channel binding [ISS, TAS]
- macrolide binding [NAS]
- peptidyl-prolyl cis-trans isomerase activity [IDA, TAS]
- protein binding [IPI]
- signal transducer activity [IMP]
- transforming growth factor beta receptor binding [ISS, TAS]
- type I transforming growth factor beta receptor binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.
The molecular chaperone Hsp90 is critical for the maintenance of cellular homeostasis and represents a promising drug target. Despite increasing knowledge on the structure of Hsp90, the molecular basis of substrate recognition and pro-folding by Hsp90/co-chaperone complexes remains unknown. Here, we report the solution structures of human full-length Hsp90 in complex with the PPIase FKBP51, as well as the 280?kDa ... [more]
Nat Commun Dec. 31, 2017; 9(1);4532 [Pubmed: 30382094]
Throughput
- Low Throughput
Curated By
- BioGRID