PPP1CA
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RUVBL2
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA, TAS]
- cellular response to UV [IMP]
- cellular response to estradiol stimulus [IMP]
- chromatin organization [TAS]
- chromatin remodeling [IMP]
- establishment of protein localization to chromatin [IMP]
- histone H2A acetylation [IDA]
- histone H4 acetylation [IDA]
- negative regulation of estrogen receptor binding [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein folding [TAS]
- transcriptional activation by promoter-enhancer looping [IMP]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
- ATP-dependent DNA helicase activity [TAS]
- ATPase activity [IDA]
- DNA helicase activity [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- chromatin DNA binding [IDA]
- identical protein binding [IDA, IPI]
- protein binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
Heart failure (HF) is a complex disease with a rising prevalence despite advances in treatment. Protein phosphatase 1 (PP1) has long been implicated in HF pathogenesis, but its exact role is both unclear and controversial. Most previous studies measured only the PP1 catalytic subunit (PP1c) without investigating its diverse set of interactors, which confer localization and substrate specificity to the ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RUVBL2 PPP1CA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3368775 | |
| RUVBL2 PPP1CA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9965 | BioGRID | 424848 | |
| PPP1CA RUVBL2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| PPP1CA RUVBL2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID