BAIT

PINK1

BRPK, PARK6
PTEN induced putative kinase 1
GO Process (37)
GO Function (11)
GO Component (17)

Gene Ontology Biological Process

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

Guardia-Laguarta C, Liu Y, Lauritzen KH, Erdjument-Bromage H, Martin B, Swayne TC, Jiang X, Przedborski S

Maintaining a pool of functional mitochondria requires degradation of damaged ones within the cell. PINK1 is critical in this quality-control process: loss of mitochondrial membrane potential causes PINK1 to accumulate on the mitochondrial surface, triggering mitophagy. However, little is known about how PINK1 is regulated. Recently, we showed that PINK1 content is kept low in healthy mitochondria by continuous ubiquitination ... [more]

J. Neurosci. Dec. 04, 2018; 39(36);7074-7085 [Pubmed: 31300519]

Throughput

  • High Throughput

Additional Notes

  • assayed using LC-MS/MS (liquid chromatography/tandem mass spectrometry)

Curated By

  • BioGRID