PDPK1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- actin cytoskeleton organization [TAS]
- activation of protein kinase B activity [IDA]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- cell migration [IMP]
- cellular response to epidermal growth factor stimulus [IMP]
- cellular response to insulin stimulus [IMP]
- epidermal growth factor receptor signaling pathway [IMP, TAS]
- extrinsic apoptotic signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intracellular signal transduction [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-threonine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of phospholipase activity [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GPC1
Gene Ontology Biological Process
- Schwann cell differentiation [ISS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan catabolic process [IDA]
- myelin assembly [ISS]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISS]
- phototransduction, visible light [TAS]
- positive regulation of skeletal muscle cell differentiation [ISS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PDPK1 GPC1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 442 | BioGRID | 3480682 |
Curated By
- BioGRID