EDNRB
Gene Ontology Biological Process
- cell surface receptor signaling pathway [TAS]
- endothelin receptor signaling pathway [IDA, IMP]
- enteric nervous system development [ISS]
- enteric smooth muscle cell differentiation [ISS]
- macrophage chemotaxis [IMP]
- negative regulation of adenylate cyclase activity [TAS]
- negative regulation of cellular protein metabolic process [IMP]
- negative regulation of neuron maturation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- nervous system development [TAS]
- vasoconstriction [IMP]
- vein smooth muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADRBK1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- cardiac muscle contraction [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of striated muscle contraction [IMP]
- negative regulation of the force of heart contraction by chemical signal [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [ISS]
- positive regulation of catecholamine secretion [ISS]
- receptor internalization [IDA]
- signal transduction [TAS]
- tachykinin receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.
Although endothelin-1 can elicit prolonged physiologic responses, accumulating evidence suggests that rapid desensitization affects the primary G protein-coupled receptors mediating these responses, the endothelin A and B receptors (ETA-R and ETB-R). The mechanisms by which this desensitization proceeds remain obscure, however. Because some intracellular domain sequences of the ETA-R and ETB-R differ substantially, we tested the possibility that these receptor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID