BAIT
SMC3
BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1
structural maintenance of chromosomes 3
GO Process (8)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HAND2
DHAND2, Hed, Thing2, bHLHa26, dHand
heart and neural crest derivatives expressed 2
GO Process (18)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- adult heart development [IEP]
- apoptotic process [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- heart development [NAS]
- heart looping [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- negative regulation of cardiac muscle cell apoptotic process [ISS]
- neural crest cell development [ISS]
- noradrenergic neuron differentiation [NAS]
- positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process [ISS]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- regulation of transcription, DNA-templated [ISS]
- thymus development [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- transcription coactivator activity [ISS]
- transcription factor binding [ISS]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- E-box binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- transcription coactivator activity [ISS]
- transcription factor binding [ISS]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.
The cohesin complex regulates sister chromatid cohesion, chromosome organization, gene expression, and DNA repair. Cohesin is a ring complex composed of four core subunits and seven regulatory subunits. In an effort to comprehensively identify additional cohesin-interacting proteins, we used gene editing to introduce a dual epitope tag into the endogenous allele of each of 11 known components of cohesin in ... [more]
J. Biol. Chem. Dec. 31, 2018; 294(22);8760-8772 [Pubmed: 31010829]
Throughput
- High Throughput
Curated By
- BioGRID