BAIT

UCK1

URK1, RP11-334J6.5

uridine-cytidine kinase 1

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (4)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

nucleobase-containing small molecule metabolic process [TAS]

pyrimidine nucleobase metabolic process [TAS]

pyrimidine nucleoside salvage [TAS]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

nucleoside kinase activity [EXP]

Gene Ontology Cellular Component

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

HSP90AA1

EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2

heat shock protein 90kDa alpha (cytosolic), class A member 1

Alzheimer's Disease Project

Arachidonic Acid Pathway Project

GO Process (16)

GO Function (10)

GO Component (10)

Gene Ontology Molecular Function

ATP binding [TAS]
ATPase activity [IDA]
MHC class II protein complex binding [IDA]
TPR domain binding [IDA, TAS]
identical protein binding [IPI]
nitric-oxide synthase regulator activity [IDA]
nucleotide binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein homodimerization activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytosol [NAS, TAS]

endocytic vesicle lumen [TAS]

extracellular region [TAS]

extracellular vesicular exosome [IDA]

mitochondrion [IDA]

nucleoplasm [IDA]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells.

Zhang H, Huang H, Feng X, Song H, Zhang Z, Shen A, Qiu X

Resistance to the chemotherapeutic drug 5'-azacytidine (5'-AZA) is a major obstacle in the treatment of patients with acute myeloid leukemia (AML). The uridine-cytidine kinase 1 (UCK1) has an established role in activating 5'-AZA and its protein level is significantly downregulated in patients resistant to the drug. However, the underlying molecular mechanism for the reduced UCK1 expression remains to be elucidated. ... [more]

Theranostics Jan. 16, 2020; 10(3);1046-1059 [Pubmed: 31938050]

Throughput

High Throughput

Curated By

BioGRID