BAIT
IL10
CSIF, GVHDS, IL-10, IL10A, TGIF, RP11-262N9.1
interleukin 10
GO Process (27)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- B cell differentiation [NAS]
- B cell proliferation [NAS]
- cell-cell signaling [IC]
- cellular response to lipopolysaccharide [NAS]
- cytoplasmic sequestering of NF-kappaB [NAS]
- hemopoiesis [TAS]
- inflammatory response [IDA]
- leukocyte chemotaxis [TAS]
- negative regulation of B cell proliferation [IDA]
- negative regulation of MHC class II biosynthetic process [TAS]
- negative regulation of T cell proliferation [NAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of interferon-alpha biosynthetic process [NAS]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of B cell apoptotic process [IDA]
- positive regulation of JAK-STAT cascade [IBA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- receptor biosynthetic process [IDA]
- regulation of gene expression [IDA]
- regulation of isotype switching [NAS]
- response to glucocorticoid [IDA]
- response to molecule of bacterial origin [IDA]
- type 2 immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPHK1
SPHK
sphingosine kinase 1
GO Process (23)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- 'de novo' posttranslational protein folding [TAS]
- calcium-mediated signaling [IDA]
- cellular protein metabolic process [TAS]
- intracellular signal transduction [TAS]
- lipid phosphorylation [IDA]
- negative regulation of apoptotic process [IDA, TAS]
- positive regulation of NF-kappaB import into nucleus [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of angiogenesis [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of mitotic cell cycle [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of smooth muscle contraction [IDA]
- protein folding [TAS]
- regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- sphingoid catabolic process [NAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
- sphingosine metabolic process [IDA]
Gene Ontology Molecular Function
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (PATO:0000169)
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic positive genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI > 1.11
Curated By
- BioGRID