BAIT
IL21R
CD360, NILR, UNQ3121/PRO10273
interleukin 21 receptor
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PIK3R1
AGM7, GRB1, IMD36, p85, p85-ALPHA
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
GO Process (32)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth hormone receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA, IPI]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- positive regulation of RNA splicing [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of transcription factor import into nucleus [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- protein stabilization [IDA]
- regulation of phosphatidylinositol 3-kinase activity [ISS]
- response to endoplasmic reticulum stress [IDA, ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (PATO:0000169)
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic positive genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI > 1.11
Curated By
- BioGRID