BAIT
ATM
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
ATM serine/threonine kinase
GO Process (23)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA repair [TAS]
- cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- histone mRNA catabolic process [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of B cell proliferation [IMP]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IMP]
- pre-B cell allelic exclusion [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- reciprocal meiotic recombination [TAS]
- replicative senescence [IMP]
- response to ionizing radiation [IDA]
- signal transduction [TAS]
- signal transduction involved in mitotic G2 DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NOD2
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
nucleotide-binding oligomerization domain containing 2
GO Process (56)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of MAPK activity involved in innate immune response [ISS]
- cellular response to muramyl dipeptide [IDA]
- cytokine production involved in immune response [IMP]
- defense response [TAS]
- defense response to bacterium [IDA]
- detection of bacterium [IDA]
- detection of biotic stimulus [TAS]
- detection of muramyl dipeptide [IDA]
- innate immune response [IDA, NAS, TAS]
- intracellular signal transduction [IDA]
- maintenance of gastrointestinal epithelium [IMP]
- negative regulation of macrophage apoptotic process [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of B cell activation [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of gamma-delta T cell activation [ISS]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of oxidoreductase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of prostaglandin-E synthase activity [ISS]
- positive regulation of prostaglandin-endoperoxide synthase activity [ISS]
- positive regulation of stress-activated MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of type 2 immune response [IMP]
- protein oligomerization [TAS]
- regulation of inflammatory response [IC]
- response to muramyl dipeptide [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
Tumorigenesis is a complex process that is driven by a combination of networks of genes and environmental factors; however, efficient approaches to identifying functional networks that are perturbed by the process of tumorigenesis are lacking. In this study, we provide a comprehensive network-based strategy for the systematic discovery of functional synergistic modules that are causal determinants of inflammation-induced tumorigenesis. Our ... [more]
ACS Synth Biol Dec. 15, 2018; 8(3);482-490 [Pubmed: 30762338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- phenotype: viability (PATO:0000169)
Additional Notes
- CRISPR GI screen
- Cell Line:NCM460 cells
- Experimental Setup: Cytokine Exposure (TGFB1)
- GIST: A-phenotypic negative genetic interaction
- Library: Targeted Library
- Significance Threshold: dGI < -0.84
Curated By
- BioGRID