BAIT
HNRNPH1
HNRPH, HNRPH1, hnRNPH
heterogeneous nuclear ribonucleoprotein H1 (H)
GO Process (5)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EGLN2
EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
egl-9 family hypoxia-inducible factor 2
GO Process (9)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cell redox homeostasis [IDA]
- cellular response to hypoxia [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- peptidyl-proline hydroxylation to 4-hydroxy-L-proline [IDA]
- positive regulation of protein catabolic process [IDA]
- regulation of cell growth [NAS]
- regulation of neuron apoptotic process [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
- ferrous iron binding [NAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- oxygen sensor activity [IDA]
- peptidyl-proline 4-dioxygenase activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [IDA]
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.
hnRNPs are polyvalent RNA binding proteins that have been implicated in a range of regulatory roles including splicing, mRNA decay, translation, and miRNA metabolism. A variety of genome wide studies have taken advantage of methods like CLIP and RIP to identify the targets and binding sites of RNA binding proteins. However, due to the complex nature of RNA-binding proteins, these ... [more]
RNA Biol Jan. 14, 2016; 13(4);400-11 [Pubmed: 26760575]
Throughput
- High Throughput
Additional Notes
- RIP-Seq
- iCLIP
Curated By
- BioGRID