BAIT
BMPR2
BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK
bone morphogenetic protein receptor, type II (serine/threonine kinase)
GO Process (30)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, ISS, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [ISS]
- artery development [ISS]
- blood vessel remodeling [ISS]
- cellular response to starvation [IEP]
- chondrocyte development [IMP]
- lung alveolus development [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- mesoderm formation [ISS]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of chondrocyte proliferation [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of vasoconstriction [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- regulation of cell proliferation [IMP]
- regulation of lung blood pressure [IMP, ISS]
- retina vasculature development in camera-type eye [ISS]
- transcription from RNA polymerase II promoter [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IDA]
- vascular endothelial growth factor receptor signaling pathway [ISS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GDF9
growth differentiation factor 9
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- BMP signaling pathway [IBA]
- SMAD protein signal transduction [IBA]
- cell development [IBA]
- female gamete generation [TAS]
- positive regulation of cell proliferation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of progesterone secretion [IDA, IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9.
Growth differentiation factor-9 (GDF-9) is a glycoprotein secreted by the oocyte that is capable of stimulating granulosa cell proliferation and inhibiting differentiation. GDF-9 is a member of the transforming growth factor beta superfamily of ligands known to signal through type I and II serine/threonine kinase receptors. In the sequenced human genome, seven type I and six type II receptors have ... [more]
Biol. Reprod. Aug. 01, 2002; 67(2);473-80 [Pubmed: 12135884]
Throughput
- Low Throughput
Curated By
- BioGRID