AKR1C3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- arachidonic acid metabolic process [TAS]
- cellular response to cadmium ion [IDA]
- cellular response to calcium ion [IDA]
- cellular response to corticosteroid stimulus [IDA]
- cellular response to jasmonic acid stimulus [IDA]
- cellular response to prostaglandin D stimulus [IDA]
- cellular response to prostaglandin stimulus [IDA]
- cellular response to reactive oxygen species [IDA]
- cellular response to starvation [IEP]
- cyclooxygenase pathway [TAS]
- daunorubicin metabolic process [IMP]
- doxorubicin metabolic process [IMP]
- farnesol catabolic process [IDA]
- keratinocyte differentiation [IEP]
- male gonad development [IEP]
- multicellular organismal macromolecule metabolic process [IEP]
- negative regulation of retinoic acid biosynthetic process [IDA]
- oxidation-reduction process [IDA, TAS]
- phototransduction, visible light [TAS]
- positive regulation of cell death [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- progesterone metabolic process [IDA]
- prostaglandin metabolic process [IEP, TAS]
- protein import into nucleus, translocation [IDA]
- regulation of retinoic acid receptor signaling pathway [IDA]
- regulation of testosterone biosynthetic process [IMP]
- renal absorption [NAS]
- response to nutrient [IEP]
- retinal metabolic process [IDA]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
- steroid metabolic process [IEP]
- testosterone biosynthetic process [IMP]
Gene Ontology Molecular Function- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase activity [IDA]
- delta4-3-oxosteroid 5beta-reductase activity [IDA]
- dihydrotestosterone 17-beta-dehydrogenase activity [IDA]
- geranylgeranyl reductase activity [IDA]
- ketoreductase activity [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- retinal dehydrogenase activity [IDA]
- retinol dehydrogenase activity [IDA]
- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase activity [IDA]
- delta4-3-oxosteroid 5beta-reductase activity [IDA]
- dihydrotestosterone 17-beta-dehydrogenase activity [IDA]
- geranylgeranyl reductase activity [IDA]
- ketoreductase activity [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- retinal dehydrogenase activity [IDA]
- retinol dehydrogenase activity [IDA]
Gene Ontology Cellular Component
AKR1C1
Gene Ontology Biological Process
- bile acid and bile salt transport [TAS]
- bile acid metabolic process [IDA]
- cellular response to jasmonic acid stimulus [IDA]
- cholesterol homeostasis [TAS]
- daunorubicin metabolic process [IMP]
- digestion [IDA]
- doxorubicin metabolic process [IMP]
- epithelial cell differentiation [IDA]
- intestinal cholesterol absorption [TAS]
- oxidation-reduction process [IDA]
- phototransduction, visible light [TAS]
- progesterone metabolic process [IDA]
- protein homooligomerization [IDA]
- response to organophosphorus [IEP]
- retinal metabolic process [IDA]
- retinoid metabolic process [TAS]
- xenobiotic metabolic process [NAS]
Gene Ontology Molecular Function- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase (B-specific) activity [IDA]
- bile acid binding [IDA]
- carboxylic acid binding [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase (B-specific) activity [IDA]
- bile acid binding [IDA]
- carboxylic acid binding [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 1.0 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 1, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AKR1C3 AKR1C1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1184407 | |
| AKR1C3 AKR1C1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2216319 | |
| AKR1C3 AKR1C1 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3744917 | |
| AKR1C1 AKR1C3 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | - |
Curated By
- BioGRID