CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
ECE1
Gene Ontology Biological Process
- bradykinin catabolic process [IDA]
- calcitonin catabolic process [IDA]
- ear development [IMP]
- embryonic digit morphogenesis [IMP]
- endothelin maturation [IDA]
- heart development [IMP]
- hormone catabolic process [IDA]
- peptide hormone processing [IDA]
- positive regulation of receptor recycling [IMP]
- protein processing [IDA]
- regulation of systemic arterial blood pressure by endothelin [IC]
- regulation of vasoconstriction [IC]
- substance P catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Weibel-Palade body [IDA]
- early endosome [IDA]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IDA]
- intrinsic component of endosome membrane [TAS]
- lysosomal membrane [IDA]
- membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- vesicle [ISS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CANX ECE1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID