BAIT
MIF
GIF, GLIF, MMIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
GO Process (21)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- carboxylic acid metabolic process [IDA]
- cell proliferation [IDA]
- cell surface receptor signaling pathway [IDA]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell aging [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive chemotaxis [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein kinase A signaling [IDA]
- prostaglandin biosynthetic process [IDA]
- protein homotrimerization [IPI]
- regulation of macrophage activation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PML
MYL, PP8675, RNF71, TRIM19
promyelocytic leukemia
GO Process (39)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [ISS]
- PML body organization [IDA, IMP]
- apoptotic process [IDA]
- cell cycle arrest [IDA]
- cellular senescence [IDA]
- circadian regulation of gene expression [ISS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum calcium ion homeostasis [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- innate immune response [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- maintenance of protein location in nucleus [IDA]
- negative regulation of angiogenesis [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of telomerase activity [IMP]
- negative regulation of telomere maintenance via telomerase [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation in response to oxidative stress [IDA]
- negative regulation of viral release from host cell [IDA]
- positive regulation of apoptotic process involved in mammary gland involution [IDA]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of histone deacetylation [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein stabilization [IDA]
- protein targeting [IDA, IMP]
- regulation of calcium ion transport into cytosol [ISS]
- regulation of circadian rhythm [ISS]
- regulation of double-strand break repair [IMP]
- regulation of protein phosphorylation [ISS]
- regulation of transcription, DNA-templated [IMP]
- response to cytokine [IDA]
- response to hypoxia [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era. We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. Our approach provides a data-driven description of the molecular and spatial networks that organize the proteome. Unsupervised clustering of these networks delineates ... [more]
Science Dec. 11, 2021; 375(6585);eabi6983 [Pubmed: 35271311]
Throughput
- High Throughput
Additional Notes
- Bait generated from library of CRISPR-edited human embryonic kidney (HEK) 293T cell lines harboring fluorescent tags on individual proteins
Curated By
- BioGRID