BAIT
AKT1
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1
GO Process (73)
GO Function (12)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- RNA metabolic process [TAS]
- T cell costimulation [TAS]
- activation-induced cell death of T cells [IMP]
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell differentiation [TAS]
- cell proliferation [TAS]
- cellular protein modification process [TAS]
- cellular response to insulin stimulus [IMP, ISS]
- endocrine pancreas development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IMP]
- insulin-like growth factor receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- mammary gland epithelial cell differentiation [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of autophagy [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of endopeptidase activity [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- negative regulation of fatty acid beta-oxidation [IMP]
- negative regulation of neuron death [NAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [NAS]
- negative regulation of plasma membrane long-chain fatty acid transport [IMP]
- negative regulation of protein kinase activity [IMP, ISS]
- negative regulation of proteolysis [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nitric oxide biosynthetic process [TAS]
- nitric oxide metabolic process [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cellular protein metabolic process [ISS]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of glycogen biosynthetic process [IMP, NAS]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein autophosphorylation [TAS]
- protein import into nucleus, translocation [IMP]
- protein phosphorylation [IDA]
- regulation of cell cycle checkpoint [TAS]
- regulation of cell migration [IMP, TAS]
- regulation of glycogen biosynthetic process [IMP]
- regulation of neuron projection development [ISS]
- regulation of nitric-oxide synthase activity [TAS]
- response to UV-A [IDA]
- response to fluid shear stress [IMP]
- response to heat [TAS]
- response to oxidative stress [ISS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IC, IDA]
- enzyme binding [ISS]
- identical protein binding [IPI]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [IMP]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- phosphatidylinositol-3,4-bisphosphate binding [IDA]
- protein binding [IPI]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [IDA, TAS]
- protein serine/threonine/tyrosine kinase activity [IDA]
- 14-3-3 protein binding [IPI]
- ATP binding [IC, IDA]
- enzyme binding [ISS]
- identical protein binding [IPI]
- kinase activity [IDA]
- nitric-oxide synthase regulator activity [IMP]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- phosphatidylinositol-3,4-bisphosphate binding [IDA]
- protein binding [IPI]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [IDA, TAS]
- protein serine/threonine/tyrosine kinase activity [IDA]
Homo sapiens
PREY
NEDD4L
NEDD4-2, NEDD4.2, RSP5, hNEDD4-2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
GO Process (33)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- cellular sodium ion homeostasis [NAS]
- excretion [NAS]
- gene expression [TAS]
- ion transmembrane transport [TAS]
- negative regulation of potassium ion transmembrane transport [IDA]
- negative regulation of potassium ion transmembrane transporter activity [IDA]
- negative regulation of protein localization to cell surface [IDA]
- negative regulation of sodium ion transmembrane transport [IDA]
- negative regulation of sodium ion transmembrane transporter activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of caveolin-mediated endocytosis [ISS]
- positive regulation of endocytosis [NAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K48-linked ubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IDA]
- regulation of ion transmembrane transport [IDA]
- regulation of membrane depolarization [IDA]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- regulation of protein catabolic process [NAS]
- response to metal ion [IDA]
- sodium ion transport [NAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- transmembrane transport [TAS]
- ventricular cardiac muscle cell action potential [ISS]
- viral life cycle [TAS]
- viral process [TAS]
- water homeostasis [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.
Akt is a Ser/Thr protein kinase that regulates cell growth and metabolism and is considered a therapeutic target for cancer. Regulation of Akt by membrane recruitment and post-translational modifications (PTMs) has been extensively studied. The most well-established mechanism for cellular Akt activation involves phosphorylation on its activation loop on Thr308 by PDK1 and on its C-terminal tail on Ser473 by ... [more]
ACS Chem Biol Dec. 21, 2021; 17(1);68-76 [Pubmed: 34941261]
Throughput
- High Throughput|Low Throughput
Curated By
- BioGRID