BAIT
CDC7
LSD6, SAS1, serine/threonine protein kinase CDC7, L000000247, YDL017W
DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p
GO Process (9)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- DNA replication initiation [IMP]
- double-strand break repair via break-induced replication [IMP]
- negative regulation of exit from mitosis [IPI]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of meiosis I [IGI]
- positive regulation of meiotic DNA double-strand break formation [IGI]
- premeiotic DNA replication [IMP]
- protein phosphorylation [IMP]
- regulation of chromatin silencing at telomere [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
RED1
L000001608, YLR263W
Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p;
GO Process (3)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis.
In budding yeast, as in other eukaryotes, the Cdc7 protein kinase is important for initiation of DNA synthesis in vegetative cells. In addition, Cdc7 has crucial meiotic functions: it facilitates premeiotic DNA replication, and it is essential for the initiation of recombination. This work uses a chemical genetic approach to demonstrate that Cdc7 kinase has additional roles in meiosis. First, ... [more]
Mol. Biol. Cell Nov. 01, 2008; 19(11);4956-67 [Pubmed: 18768747]
Throughput
- Low Throughput
Ontology Terms
- phenotype: sporulation (APO:0000041)
- phenotype: inviable (APO:0000112)
Additional Notes
- double mutants produce inviable spores
Curated By
- BioGRID