BAIT

SOD1

CRS4, superoxide dismutase SOD1, L000001978, YJR104C
Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p and enters the nucleus under oxidative stress to promote transcription of stress response genes; human ortholog implicated in ALS; abundance increases under DNA replication stress and during exposure to boric acid; localization of a fraction to the mitochondrial intermembrane space is modulated by the MICOS complex
Saccharomyces cerevisiae (S288c)
PREY

PHO80

AGS3, TUP7, VAC5, phoR, L000001426, YOL001W
Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection.

Reddi AR, Jensen LT, Naranuntarat A, Rosenfeld L, Leung E, Shah R, Culotta VC

In various organisms, high intracellular manganese provides protection against oxidative damage through unknown pathways. Herein we use a genetic approach in Saccharomyces cerevisiae to analyze factors that promote manganese as an antioxidant in cells lacking Cu/Zn superoxide dismutase (sod1 Delta). Unlike certain bacterial systems, oxygen resistance in yeast correlates with high intracellular manganese without a lowering of iron. This manganese ... [more]

Free Radic. Biol. Med. Jan. 15, 2009; 46(2);154-62 [Pubmed: 18973803]

Throughput

  • Low Throughput

Ontology Terms

  • oxidative stress resistance (APO:0000083)
  • vegetative growth (APO:0000106)

Additional Notes

  • deletion of PHO80 causes growth defect in response to oxidative stress

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SOD1 PHO80
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
568291

Curated By

  • BioGRID