BAIT

PKC1

CLY15, CLY5, CLY7, HPO2, STT1, protein kinase C, L000001446, L000000362, S000029091, YBL105C
Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
Kinome Project (Sc)
Saccharomyces cerevisiae (S288c)
PREY

CIK1

L000000335, YMR198W
Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog, VIK1, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

The functional relationships underlying a synthetic genetic network.

Krause SA, Gray JV

Here, we focus on synthetic lethal genetic interactions, examples of genetic enhancements, where mutations in two different genes result in lethality but only when present together. We recently identified the synthetic lethal network around the PKC1 gene encoding the essential protein kinase C of yeast. We found that this network is heavily enriched for interactions with genes whose products are ... [more]

Commun Integr Biol Aug. 26, 2009; 2(1);4-6 [Pubmed: 19704853]

Throughput

  • Low Throughput

Ontology Terms

  • resistance to chemicals (APO:0000087)
  • necrotic cell death (APO:0000220)

Additional Notes

  • A chemical-genetic analysis showed that null mutations in CIK1, ACK1 or SWI4 worsen the extent of cell lysis caused by the Pkc1 inhibitor staurosporine.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PKC1 CIK1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
327804

Curated By

  • BioGRID