BAIT
MDH1
HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2
malate dehydrogenase 1, NAD (soluble)
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AKR1C3
DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
aldo-keto reductase family 1, member C3
GO Process (37)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- arachidonic acid metabolic process [TAS]
- cellular response to cadmium ion [IDA]
- cellular response to calcium ion [IDA]
- cellular response to corticosteroid stimulus [IDA]
- cellular response to jasmonic acid stimulus [IDA]
- cellular response to prostaglandin D stimulus [IDA]
- cellular response to prostaglandin stimulus [IDA]
- cellular response to reactive oxygen species [IDA]
- cellular response to starvation [IEP]
- cyclooxygenase pathway [TAS]
- daunorubicin metabolic process [IMP]
- doxorubicin metabolic process [IMP]
- farnesol catabolic process [IDA]
- keratinocyte differentiation [IEP]
- male gonad development [IEP]
- multicellular organismal macromolecule metabolic process [IEP]
- negative regulation of retinoic acid biosynthetic process [IDA]
- oxidation-reduction process [IDA, TAS]
- phototransduction, visible light [TAS]
- positive regulation of cell death [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- progesterone metabolic process [IDA]
- prostaglandin metabolic process [IEP, TAS]
- protein import into nucleus, translocation [IDA]
- regulation of retinoic acid receptor signaling pathway [IDA]
- regulation of testosterone biosynthetic process [IMP]
- renal absorption [NAS]
- response to nutrient [IEP]
- retinal metabolic process [IDA]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
- steroid metabolic process [IEP]
- testosterone biosynthetic process [IMP]
Gene Ontology Molecular Function- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase activity [IDA]
- delta4-3-oxosteroid 5beta-reductase activity [IDA]
- dihydrotestosterone 17-beta-dehydrogenase activity [IDA]
- geranylgeranyl reductase activity [IDA]
- ketoreductase activity [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- retinal dehydrogenase activity [IDA]
- retinol dehydrogenase activity [IDA]
- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- aldo-keto reductase (NADP) activity [TAS]
- androsterone dehydrogenase activity [IDA]
- delta4-3-oxosteroid 5beta-reductase activity [IDA]
- dihydrotestosterone 17-beta-dehydrogenase activity [IDA]
- geranylgeranyl reductase activity [IDA]
- ketoreductase activity [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- retinal dehydrogenase activity [IDA]
- retinol dehydrogenase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.761)
Curated By
- BioGRID