BAIT
PDPK1
PDK1, PDPK2, PDPK2P, PRO0461
3-phosphoinositide dependent protein kinase 1
GO Process (29)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- actin cytoskeleton organization [TAS]
- activation of protein kinase B activity [IDA]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- cell migration [IMP]
- cellular response to epidermal growth factor stimulus [IMP]
- cellular response to insulin stimulus [IMP]
- epidermal growth factor receptor signaling pathway [IMP, TAS]
- extrinsic apoptotic signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intracellular signal transduction [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-threonine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of phospholipase activity [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TGFBR3
BGCAN, betaglycan
transforming growth factor, beta receptor III
GO Process (22)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [ISS]
- cell growth [ISS]
- cell migration [ISS]
- definitive erythrocyte differentiation [ISS]
- definitive hemopoiesis [ISS]
- epithelial to mesenchymal transition [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- immune response [IMP]
- intracellular signal transduction [IMP]
- liver development [ISS]
- negative regulation of cellular component movement [IDA]
- negative regulation of epithelial cell proliferation [ISS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IMP]
- response to follicle-stimulating hormone [IDA]
- response to luteinizing hormone [IDA]
- response to prostaglandin E [IDA]
- transforming growth factor beta receptor signaling pathway [IDA, IMP]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 204.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID