BAIT
PDK4
pyruvate dehydrogenase kinase, isozyme 4
GO Process (17)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to fatty acid [IMP]
- cellular response to starvation [IDA]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [IMP]
- negative regulation of anoikis [IMP]
- protein phosphorylation [IDA, ISS, TAS]
- pyruvate metabolic process [TAS]
- reactive oxygen species metabolic process [IMP]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP, TAS]
- regulation of cellular ketone metabolic process [ISS]
- regulation of fatty acid biosynthetic process [IMP]
- regulation of fatty acid oxidation [ISS]
- regulation of glucose metabolic process [IMP]
- regulation of pH [ISS]
- response to starvation [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CCT8
C21orf112, Cctq, D21S246, PRED71
chaperonin containing TCP1, subunit 8 (theta)
GO Process (4)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Mol Cell Dec. 06, 2019; 79(3);504-520.e9 [Pubmed: 32707033]
Quantitative Score
- 57.61111111 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Curated By
- BioGRID