WNK3
Gene Ontology Biological Process
- intracellular signal transduction [ISS]
- negative regulation of apoptotic process [IMP]
- positive regulation of calcium ion transport [IMP]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of ion transmembrane transporter activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of rubidium ion transmembrane transporter activity [IDA]
- positive regulation of rubidium ion transport [IDA]
- positive regulation of sodium ion transmembrane transporter activity [IDA, IMP]
- positive regulation of sodium ion transport [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [ISS]
- regulation of ion homeostasis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNK1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a ... [more]
Quantitative Score
- 20536.0 [Protein Abundance Ratio]
Throughput
- High Throughput
Additional Notes
- Affinity Capture-MS was carried out to identify high confidence protein-protein interactors with a FDR<1% (protein abundance ratio compared to control are reported)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNK1 WNK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3375202 | |
| WNK1 WNK3 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3677399 | |
| WNK1 WNK3 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.0342 | BioGRID | 3584538 |
Curated By
- BioGRID